Photodynamic Therapy in Non-Surgical Treatment of Periodontitis: A Systematic Review and Meta-Analysis

Aim: to evaluate the adjunctive effects of photodynamic therapy (aPDT) on nonsurgical mechanical treatment in patients with periodontitis. Materials and methods: The search strategy was conducted according PRISMA guidelines answer research questions regarding effectiveness aPDT association non-surgical periodontal therapy. mean values standard deviations were collected by data extraction. A descriptive comparison between alone performed, meta-analyses PPD also performed. Both randomized controlled clinical trials (RCTs) (CCTs) included. Results: Out 2059 records, 14 articles included because they met eligibility criteria. control group showed improved for (SMD −0.76, p = 0.003; I2 88%). Statistical analysis then applied three subgroups. first studies that used indocyanine green a wavelength 810 nm −1.79, < 0.00001, second phenothiazine chloride at 660 −0.03, 0.84, 0%). last methylene blue photosensitizers treated 628–670 −0.13, 0.38; Conclusions: despite limited number RCTs great heterogeneity them, it can be concluded parameters 3 months.